Klik hieronder voor meer info:
Topical glycopyrrolate reduces axillary hyperhidrosis.
Oral anti-cholinergic medications reduce generalized hyperhidrosis, but the effectiveness of topical anticholinergic solutions on axillary hyperhidrosis is unclear. This study determines the initial effectiveness of 1% and 2% topical glycopyrrolate spray and compares this with Botulinum toxin type A injections for the management of axillary hyperhidrosis.
In a non-randomized, consecutive patient, prospective questionnaire, treatment comparison study, 40 patients with axillary hyperhidrosis were allocated to one of four study groups (10 patients to each group): (a) 1% glycopyrrolate spray, (b) 2% glycopyrrolate spray, (c) subcutaneous Botulinum toxin type A injections, (d) no treatment. Clinical outcomes were measured by comparing a prospectively administered questionnaire, completed both pre-treatment and 6 weeks after starting treatment. Forty healthy volunteers without axillary hyperhidrosis completed the same questionnaire.
The three treatment groups showed a significant (P < 0.05) improvement in their hyperhidrosis scores following treatment. The degree of improvement was less for the 1% glycopyrrolate group when compared with the Botulinum toxin type A group (P < 0.05), but there was no difference in treatment outcomes between the 2% glycopyrrolate and Botulinum toxin type A groups. No treatment group experienced reduced hyperhidrosis to a level similar to those without hyperhidrosis. Patients in both, the 2% glycopyrrolate and Botulinum toxin type A groups reported a significant improvement in axillary hyperhidrosis symptoms. These included reduction in psychologically precipitating factors (e.g. public speaking) and axillary hyperhidrosis-specific physical effects (e.g. limitation of clothing choice).
Topical glycopyrrolate spray could provide a further treatment modality to manage axillary hyperhidrosis.
© 2016 European Academy of Dermatology and Venereology.
PMID: 27406319 DOI: 10.1111/jdv.13745
Wim Venema - Dermatoloog Wilhelmina Ziekenhuis Assen
Geen flauw idee of en hoe ze leveren naar Nederland en of dat kan zonder recept maar in de VS bestaat het dus al. Kwestie van tijd voordat het naar Nederland komt hoop ik.
- Vergelijkbare Onderwerpen
- Laatste bericht